Immunology and Immunotherapy
Our lab studies innate and adaptive host immune cell biology, function and communication in homeostatic as well as in pathological conditions such as in the Tumor Microenvironment (TME).
Cells of the immune system constantly monitor and eliminate cancer cells throughout the lifespan of an organism. Tumors, in turn, have developed various mechanisms to evade immune surveillance. State-of-the-art immunotherapies interfere with these mechanisms to facilitate immune cell-mediated eradication of tumor cells. However, while successful for some patients and certain types of cancer, immunotherapy efficacy is still limited. To improve treatments and overcome tumor evasion mechanisms, it is crucial to gain a deeper understanding of immune-tumor interactions.
We aim to comprehensively map the entire spectrum of interactions between immunocytes and the TME, which plays a crucial role in supporting the tumor, by identifying negative and positive tumor regulator programs, studying localization mediated effects, and mapping the genetic and epigenetic mediators that take part in the immune-TME interplay.
We screen potential candidates for targeted combination therapy in-vivo, and in a tumor slice culture system that allows testing in parallel mouse and human fresh tissues to uncover pro- and anti-tumor molecular mechanisms that could inform the creation of more effective combination immunotherapies.
Our new lab
Our spacious lab, overlooking the beautiful Bat-Galim beach is fully equipped and offers all the necessary resources to conduct excellent science. We are looking forward to working on our various diverse research projects and to exploring new ideas.
We are recruiting
Looking for driven, curious, hardworking and ambitious people who are excited about research